13th International Symposium on Polymer Therapeutics: from Laboratory to Clinical Practice

ISPT Conference 2022

23rd - 25th May 2022

Prices for the Best Oral Presentation & for the Best Poster

About Event

From Laboratory to Clinical Practice

Welcome to the International Symposium on Polymer Therapeutics to be held in Valencia.A chance for world-renowned scientists to share their recent research and vision for the future of Polymer Therapeutics to attendees in the context of interdisciplinary research at the interface of biology, chemistry, pharmaceutical sciences, and medicine.

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Discussion Leaders

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Featured Speakers

The Speakers

Children's Cancer Institute; the Lowy Institute, Randwick. Studio photography of executives and senior researchers.

Maria Kavallaris Head of Translational Cancer Nanomedicine at Children’s Cancer Institute, UNSW

Professor Kavallaris is an interdisciplinary researcher who is advancing cancer nanomedicine. Her discoveries have led to patents, and industry and clinical linkages for the development of cancer therapeutics and devices.

Anand Subramony Vice President of External innovation and Novel Technologies at AstraZeneca

In this role, he leads various cross functional teams and initiatives in the areas of nanomedicine, targeted delivery, new modalities/ tech platforms, antibody drug conjugates and lab automation technologies.

Mustafa Diken Vicepresident Vaccines and Immunology at BioNTech

Received his Ph.D. in tumor immunology from Johannes Gutenberg University under the supervision of Prof. Ugur Sahin

Susan-Napier-Thomas-scaled-e1639155794501

Susan Napier Thomas Woodruff Associate Professor at the Georgia Institute of Technology

Susan Napier Thomas is a Woodruff Associate Professor with tenure at the Georgia Institute of Technology developing immunotherapeutic drug delivery systems.

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Event details

The latest and most exciting developments in polymer technology and the biological and clinical disciplines relating to Polymer Therapeutics.

New in polymer therapeutics

A chance for world-renowned scientists to share their recent research and vision for the future of Polymer Therapeutics to attendees in the context of interdisciplinary research at the interface of biology, chemistry, pharmaceutical sciences, and medicine.

23rd May
24th May
25th May

Registration

08.30 AM - 11.00 AM

Registration. Montage of Posters and Exhibition

Welcome

11.00 AM - 11.30 AM

Welcome & Opening Remarks

Plenary Lecture

11.30 AM - 12.15 AM

Plenary Lecture

Discussion Leader: Matthias Barz (Univ Leiden, NL)

11.30 Mustafa Diken (BioNTech, DE) mRNA vaccines for cancer and beyond

Speakers sessions

12.15 PM - 13.50 PM

Rationally designed Non-Viral Gene Delivery Vectors

Discussion leader: Julen Oyarzabal (Tyris Therapeutics Spain)

12.15 Daniel Siegwart (UT Southwestern Medical Center, USA)

Zwitterionic phospholipidation of cationic polymers facilitates systemic mRNA delivery to the spleen and lymph nodes.

12.45 Satoshi Suchida (Kyoto Prefectural University of Medicine, JP) Polymer Therapeutics for efficient mRNA delivery

13:15 Yao Jin (Ludwig-Maximilians-University Munich, DE) Synthesis and application of spermine-based poly(β-amino Ester)s for siRNA delivery

13.25 Zerong Ma (UNSW Sydney, AUS) Miktoarm star polymer nanoparticles enable siRNA delivery for the treatment of lung cancer

13.35 Stefano Salmaso (Univ Padova, IT) Lipoplex-Mediated Oligonucleotide Delivery: Enhanced Crossing of Cell Barriers

13.40 Gabriela Arias Alpizar (Univ Leiden, NL) Elucidating Nanoparticle Behavior Using Zebrafish

13.45 Anna Scomparin (Univ Turin, IT) Alkylic-Cyclodextrin Cationic Polymers: A Novel siRNA Delivery System for Glioblastoma Therapy

Lunch

13.50 PM - 15.15 PM

Lunch & Poster Session I

Enjoy our poster exhibition during lunch time.

Speakers sessions

15.15 PM - 17.15 PM

Engineering Polymer Therapeutics for Immunomodulation I

Discussion Leader: Ronit Satchi-Fainaro (Tel Aviv Univ, IL)

15.15 Susan N. Thomas (Georgia Tech, USA) Polymer drug delivery systems
for immunotherapeutic drug delivery to the lymphatic system

15.45 Lutz Nuhn (Univ Mainz, Germany) Macromolecule-Based Strategies For
Enhancing Immunotherapy Responses By Macrophage Repolarization

16.15 Helena Florindo (Univ Lisbon, PT) Multivalent Anticancer NanoVaccines

16.45 Bárbara Ibarzo Yus (UCL, UK and IBEC, SP) PMPC-PDPA polymersomes in cancer vaccine development

16.55 Liane Moura (iMed. ULisboa, PT) Multivalent branched poly-l-glutamic acid-based nanovaccine sensitizes melanoma to anti-PD1 therapy

17.05 Francesca Mastrotto (Univ Padova, IT) Mannosylated polycations for therapeutic nucleic acid Delivery in cancer vaccination

Coffee break

17.15 PM - 17.45 PM

Coffee break & Posters-Exhibition

Enjoy our poster exhibition during lunch time.

Round Table Discussion

17.45 PM - 19.15 PM

How can Polymer Therapeutics Improve Global Healthcare?

An Interactive Session

17.45 – 19:15 Round Table Discussion: Including topics such as identifying Unmet needs: Drug targets and Diseases, Modalities needs – expanded space; Patient’s needs; Needs on Clinical Translation, such as, Characterization techniques and other capabilities or New advances on disruptive polymer sciences.

Discussion co-Leaders:

Marianne B. Ashford (AstraZeneca, UK) and Manuel Sánchez-Félix (Novartis, USA).

Ruth B. Schmid (Sintef, No)

Cameron Alexander (Univ Nottingham, UK)

Poster Session

19.15 PM - 20.30 PM

Poster Session II

Interactive session

Conference Reception

20.30 PM

Conference Opening Reception

Plenary speaker

09.00 AM - 9.45 AM

Plenary Lecture II

Discussion Leader: Andrew Lewis (Quotient Sciences, UK)

9.00 Maria Kavallaris (UNSW, AUS)

(UNSW, AUS) Advanced Diagnostics and Therapeutics for Pediatric Cancers

Speakers Sessions

09.45 AM - 11.20 AM

Tackling Childhood Diseases

Discussion Leaders: Andrew Lewis (Quotient Sciences, UK)

9.45 Maria J. Blanco (Univ Navarra, Sp) Nanomedicines for the treatment of
Pediatric diseases

10.15 Mohammed Balogun (CSIR, SouthAfrica) Rational Design of Polymer Conjugates for the treatment of malaria in children

10.45 Gloria García Palacios (Sanofi. France) Overview of EU and FDA Pediatric Regulations

11.15 Tetiana Melnyk (CIPF, SP) A Polyglutamate-Based Intranasal Drug Delivery Platform for Pediatric Glioma Treatment.

Coffee break

11.20 AM - 11.45 AM

Coffee break & Poster Session

Enjoy our poster and Exhibition.

Short Talks

11.45 PM - 12.45 PM

Tackling Diseases other than Cancer

11:45 Paco Fernandez-Trillo (Univ Birmingham, UK)

Delivery of Antimicrobials through Peptide and Responsive Chemistry

11:55 Patrick Weber (ETH Zürich, SW)

Zwitterionic polymer-drug conjugates with lubricating, anti-inflammatory activity for the treatment of osteoarthritis

12:05 Elaine Ferguson (Cardiff Univ, UK)

Dextrin conjugation prevents colistin-induced acute kidney injury in mice

12:15 Tommaso Tedeschini (Univ Pavoda, IT)

Pegylated peptide-cleavable linkers designed to provide stable and active antibody-drug conjugates.

12:25 Silvia Acosta-Gutierrez (UCL, UK)

A Multiscale Study of Phosphorylcoline Driven Cellular Phenotypic Targeting

12:30 Zsuzsa Baranyai (INMA, SP)

Antitubercular Drug Delivery with Polysaccharide-Based Nanocarriers

12:35 Alexander Lamoot (Univ Ghent, BE)

Lipid Nanoparticles encapsulating PolyI:C A Potent Adjuvant for Recombinant Spike S1 SARS-CoV-2 vaccination

12.40 Antonella Grigoletto (Univ Padova, IT)

Stability and in-vivo profile of a new circular site-specific PEGylated G-CSF

Speakers Sessions

12.45 PM - 13.45 PM

Advances of Polymer Therapeutics in the Clinics I

Discussion Leaders: Michael Wagner (DE)

12.45 Cristianne Rijcken (Cristal Therapeutics, NL)

Conception till Clinical Translation of Core-Crosslinked (CRIPEC®) Polymeric Micelles and Product Diversification

13.15 Michael Bevilacqua (Amicrobe, USA)

AmicidinsTM: Synthetic Biologics Headed into Clinical Trials in Surgery and Trauma

Speaker

Lunch

13.45 PM - 15.00 PM

Lunch & Poster Session III

Enjoy the poster and Exhibition during Lunch time

Round table discussion

15.00 PM - 16.45 PM

Round table discussion

Session in honor to Prof Hiroshi Maeda. Father of the EPR effect and a Giant in our field

15.00 – 16:45 Round Table Discussion: Fundamentals of EPR and tumor targeting, on novel insights related to transcytosis, hitchhiking and macrophage retention, on practical aspects of dealing with EPR variability, and on how to move “passively targeted” cancer nanomedicines forward both clinically and industrially.

Discussion Leader: Twan Lammers (RWTH Aachen University Clinic, DE)

Milles A. Miller (MGH Center Systems Biology, Harvard Med School, USA)

Khaled Greish (Al-Jawhara Centre, Kingdom of Bahrain)

Warren Chan (Univ Toronto, CA

Short Talks

16.45 PM - 17.30 PM

Rationally Design Anticancer Polymer Therapeutics

Discussion Leader: Ana Armiñán (CIPF, SP)

16:45 Fernanda Rodríguez-Otormín (CIPF, SP) A rationally designed polypeptide-based combination conjugate for the treatment of metastatic triple negative breast cancer

16:50 Mariana Bento (iMed Univ Lisboa, PT) Multifunctional Polymeric Nanoplatform to Overcome Pancreatic Cancer Immune Evasion

16:55 Paul Strasser (Johannes Kepler University Linz, Aus) Bottlebrush, High-Molecular-Weight Polyphosphazene-G-Poly (L-Glutamic Acid) As Fully Biodegradable Polymer Therapeutics

17:00 Paz Boix-Montesinos (CIPF, SP) The Development and Characterization of Advanced In Vitro Models for the Evaluation of Polypeptide-Drug Conjugates

17:05 Diana Matias (UCL, UK) Polymersomes With Tunable Avidity to LRP1 In Healthy and Glioma Model

17:10 Carmen Moya-Lopez (Univ Lorraine, FR) Multifunctional PLA/Gelatin Bionanocomposites for Tailored Drug Delivery Systems

17:15 Antoni Serrano (CIPF, SP) Optimization of Preclinically Relevant Three-Dimensional Prostate Cancer Models

Poster Session

17.20 PM - 17.45 PM

Coffee & Tea Posters

Interactive Session

Speakers Sessions

17.45 PM - 19.30 PM

Novel Synthetic approaches and Exhaustive Characterisation Techniques

Discussion Leaders: Cameron Alexander (Univ Nottingham, UK)

17:45 Adam Gormley (Rutgers Univ , USA)- Discovering Advanced polymeric systems by an Automated and AI-driven polymer chemistry platform.

18.15 Roey Amir (Tel Aviv Univ, IL) Architectural changes as a tool for controlling the stability and reactivity of polymeric assemblies.

18.45 Robert Luxenhofer (Helsinki Univ, FI), and Ann-Christin Pöppler (Univ Würzbug, DE) Taking up the chase with NMR Spectroscopy – From structural
insights into solid drug-polymer formulations to their fate in biorelevant media.

19.15 – Sebastien Rouzeau (Tosoh Biosciences, DE) Polymer therapeutics deserve a better light

Poster Session

19.30 PM - 21.00 PM

Coffee break & Poster Session IV

Interactive Session

* Refreshment will be provided

Plenary Lecture

09.00 AM

Plenary Lecture III

Discussion Leader: María J. Vicent (CIPF, SP)

9.00 Anand Subramony (AstraZeneca, USA) Targeted Nanomedicines
Bench to Bedside

Speakers sessions

09.45 AM - 10.45 PM

Advances of Polymer Therapeutics in the Clinics II

Discussion Leaders: Peter Turecek (Takeda, Austria)

09.45 Marisol Quintero (Highlight Therapeutics, SP) BO-112: local immunotherapy for Advanced tumors. Phase I-II studies.

10.15 Anthony Cheung (Engene Therapeutics, Canada)

EG-70: A clinical stage drug candidate for non-muscle invasive bladder cancer utilizes a novel polymer-based non-viral vectors for delivery of immune modulators

Coffee break

10.45 AM - 11.15 AM

Coffee / Tea Posters

Enjoy our poster Exhibition.

Speakers sessions

11.15 AM - 13.25 PM

Crossing Challenging Biological Barriers and Understanding Cellular Trafficking

Discussion Leader: Giuseppe Battaglia (UCL, UK and IBEC, SP)

11.15 Ronit Satchi-Fainaro (Tel Aviv Univ., IL) Modulating the Brain Immune System

11.45 Daniel Gonzalez-Carter (IBEC, SP) Exploiting the physiology of the blood-brain barrier to generate artificial brain targets for polymeric nanoparticle delivery

12.15 Inmaculada Conejos-Sánchez (CIPF, SP) Treating Neurodegeneration with A Polypeptide-Based Combination Approach Tackling Oxidative Stress and Inflammation Pathways

12.30 Marcelo Calderón (POLYMAT, SP) Multiresponsive nanogels for transmucosal drug delivery

12.45 Alexander N. Zelikin (Aarhus University, Denmark) Polymer therapeutics + albumin and/or antibodies = superior drug carriers

13.00 Snežana Đorđević (CIPF, SP) Mass Spectrometry Imaging as an Emerging Tool for the Rational Design of Polypeptide-Drug Combination Conjugates

13:05 Camilla Pegoraro (CIPF, SP) The Development of Novel Polypeptide-Based Drug Delivery Platforms for Mitochondrial Targeting

13:10 Rafael Miravet Martí (PTS, SP) Poly(sarcosine)-VitE (TPSS) as alternative to poly(ethylene glycol)- VitE (TPGS).

Speakers

Lunch

13.25 PM - 14.45 PM

Lunch and Posters Session V

Enjoy the poster and Exhibition during Lunch time

Speakers sessions

14.45 PM - 17.15 PM

Do we always need PEG replacement?

Discussion Leaders: Vicent J Nebot (PTS SL, SP)

14.45 Gianfranco Pasut (Univ Padova, IT) The role and impact of polyethylene glycol on anaphylactic reactions to COVID-19 nano-vaccines

15.15 Matthias Barz (Leiden Univ, NL) Polysarcosine: More than an Alternative to PEG?

15.45 Nicola Tirelli (IIT, NIT) Protein Conjugation with Ros-Scavenging Polymers

16.00 – 17.15 Round Table Discussion. Understanding when PEG and its alternatives should be use.

Discussion Leaders: Gianfranco Pasut (Univ Padova, IT) and Matthias Barz (Leiden Univ, NL)

Vicent J Nebot (PTS, SP)

Ralf Kraehmer (Celares, DE)

Peter Turecek (Takeda, Austria)

Coffee break

17.15 PM - 17.30 PM

Coffee Break & Posters Session

Speakers sessions

17.30 PM - 19.30 PM

New Imaging Technologies and Targeting Strategies

Discussion Leader: Alexander Zelikin (Aarhus Univ, DK)

17.30 Fabian Kiessling (Univ Aachen, Germany) Polymer-based Molecular Imaging probes, Theranostics and Companion diagnostics

18.00 Eric Allémann (Université de Genève, SW) Vascular-Targeted Micelles as MRI Contrast Agents for Molecular Imaging

18:30 Christopher Eggers (Promega, USA) Bioluminescence-Based Assays for Monitoring Delivery of Therapeutic Molecules into Live Cells.

18:45 Valentino Barbieri (UCL, UK) Hybrid Au-polymer vesicles as photoactivated nanomedical devices

18:55 Roman A. Barmin (RWTH Aachen University Hospital, DE) Surfactants to tailor the acoustic response and drug loading capacity of PBCA-based polymeric microbubbles

19:05 María Alleva (INMA, SP) Interaction between polysaccharide nanocapsules and biological barrier models

19:10 María Medel (CIPF, SP) The Design of Polypeptide-Based Nanoconjugates as Advanced Theranostics

19:15 Mohit Kumar (IBEC, SP) In situ Labelling and STED Based Super Resolution Imaging of Peptide Nanostructures

Speakers

Prizes

19.30 PM

Prizes for best poster & oral communications. Concluding Remarks

Gala Dinner

20.30 PM

Gala Dinner

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Great opportunities for the active participation of young scientists from around the world through a number of Travel Grants to support attendance.

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News on industrial and medical progress in the transfer of Polymer Therapeutics from the laboratory to the clinic.

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